In the 1970s two 14-year-olds -- beautiful party girl Tully (Katherine Heigl) and bookish, shy Kate (Sarah Chalke) -- become neighbors and best friends. Over the decades the two are inseparable, as they go to college together, start journalism careers at the same small Seattle TV news station, and compete for the affections of their rakish boss, Johnny (Ben Lawson). The show ping-pongs primarily between their teen experiences and their careers and personal lives in the '80s and the 2000s, when Tully has become an Oprah-like sensation and Kate, now a mom to her own 14-year-old, is reentering the workforce after splitting from (spoiler!) Johnny.
